I think, there is no strategy existing that leads us through the game from the beginning until the end.
We have to adapt our handling to the efforts in personal game statuses.
In the beginning of my game here, I decided to build every sort of building, manufactories too. This helped me very much to proceed and survive the harad times. Because I hadn't anything to trade with nor I had surplus of money or supplies. Getting higher in Research-Tree and having higher level buildings and so on, my stocks began to fill.
Following the hints here in the forum I sold my non-boosted manus - but I regress this now. Why?
I've got a new Main-Quest which orders to build '2 different advanced manus' I dont have a boost on. The only way to solve this is: build from the beginning and waste lots of time, money, goods.
Today I'm thinking: towards approaching the last tier in the Research-Tree, having enough resources, maybe I'll build non-boosted manus again (without being forced by Quests) - to produce goods by myself an then helping neighbours with offers everyone can buy cheap.